Targeting DNA Hairpin Loops with their Partially Complementary Strands
نویسندگان
چکیده
منابع مشابه
The Size of the Internal Loop in DNA Hairpins Influences Their Targeting with Partially Complementary Strands
Targeting of noncanonical DNA structures, such as hairpin loops, may have significant diagnostic and therapeutic potential. Oligonucleotides can be used for binding to mRNA, forming a DNA/RNA hybrid duplex that inhibits translation. This kind of modulation of gene expression is called the antisense approach. In order to determine the best strategy to target a common structural motif in mRNA, we...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.3600